Stiripentol for dravet syndrome: is it worth it?
نویسنده
چکیده
منابع مشابه
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
PURPOSE To review the efficacy and tolerability of stiripentol in the treatment of U.S. children with Dravet syndrome. METHODS U.S. clinicians who had prescribed stiripentol for two or more children with Dravet syndrome between March 2005 and 2012 were contacted to request participation in this retrospective study. Data collected included overall seizure frequency, frequency of prolonged seiz...
متن کاملThe European patient with Dravet syndrome: Results from a parent-reported survey on antiepileptic drug use in the European population with Dravet syndrome
Dravet syndrome is a rare form of epilepsy largely refractory to current antiepileptic medications. The only precedents of randomized placebo-controlled trials in Dravet syndrome are the two small trials that led to the approval of stiripentol. With the arrival of new clinical trials for Dravet syndrome, we sought to determine the characteristics of the patient population with Dravet syndrome i...
متن کاملResponse to the comments on ‘Acute hepatic injury in a child with Dravet syndrome: No protective effect of stiripentol’
Goorhuis et al. add some very important information about the problem of medication-induced hepatotoxicity in children with Dravet syndrome. The girl they describe was treated with valproic acid, stiripentol and acetaminophen. Stiripentol is thought to prevent liver damage in acetaminophen intoxication. Stiripentol inhibits the synthesis of N-acetyl-pbenzoquinone-imine, a highly reactive acetam...
متن کاملCurrent therapeutic procedures in Dravet syndrome.
Dravet syndrome is a highly pharmaco-resistant form of epilepsy. Valproate and benzodiazepines are the first-line treatment but are usually insufficient therapeutic options. Lamotrigine, carbamazepine and high doses of intravenous phenobarbital can aggravate seizures and should be avoided. Topiramate, levetiracetam, bromide and ketogenic diet also provide substantial efficacy as adjunctive ther...
متن کاملLong-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan.
BACKGROUND We have previously shown the benefits of short-term add-on stiripentol therapy for Dravet syndrome inadequately controlled by clobazam and valproate in Japanese patients. We report here the outcomes of long-term stiripentol use. METHODS Patients with Dravet syndrome having ≥4 clonic/tonic-clonic seizures per 30 days while on clobazam and valproate (with or without bromide) received...
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عنوان ژورنال:
- Epilepsy currents
دوره 14 1 شماره
صفحات -
تاریخ انتشار 2014